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Haematopoietic stem cell transplantation literature review

Hematopoietic stem-cell transplantation HSCT is the transplantation of multipotent hematopoietic stem cells , usually derived from bone marrow , peripheral blood , or umbilical cord blood. It is most often performed for patients with certain cancers of the blood or bone marrow , such as multiple myeloma or leukemia. Infection and graft-versus-host disease are major complications of allogeneic HSCT. HSCT remains a dangerous procedure with many possible complications; it is reserved for patients with life-threatening diseases. As survival following the procedure has increased, its use has expanded beyond cancer to autoimmune diseases [4] [5] and hereditary skeletal dysplasias ; notably malignant infantile osteopetrosis [6] [7] and mucopolysaccharidosis.
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Hematopoietic stem cell transplantation

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Hematopoietic Stem Cell Transplantation - StatPearls - NCBI Bookshelf

Metrics details. Patients undergoing hematopoietic stem cell transplantation HSCT have a higher risk of developing secondary solid tumors, in particular squamous cell carcinoma, because of several risk factors, including full-body irradiation TBI , chemotherapy, and chronic graft versus host disease GVHD. Based on the review presented here, a classification of oral changes is suggested in order to provide a tool to detect high-risk patients. The literature over the last 30 years was reviewed for development of malignoma of the oral cavity after HSCT.
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The safety of kidney transplantation KT for end-stage kidney disease ESKD after haematopoietic stem cell transplantation HSCT for haematological disease has not been investigated thoroughly. Data for six such patients were obtained from three institutions in our consortium. Two patients with chronic myeloid leukaemia, one with refractory aplastic anaemia and another one with acute lymphocytic leukaemia received bone marrow transplantation.
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Objective: This article reviews recent literature on adults' quality of life following hematopoietic stem cell transplantation HSCT. Methods: We identified 22 prospective reports with at least 20 participants at baseline through a search of databases Medline and PsycInfo and handsearching of articles published from to October If longitudinal data were not available or were scarce for a particular topic or time point, cross-sectional studies were reviewed.
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